The Role of Interleukin-6 (IL-6) in Human Sulfur Mustard (HD) Toxicology
نویسندگان
چکیده
منابع مشابه
Neutralization effects of interleukin-6 (IL-6) antibodies on sulfur mustard (HD)-induced IL-6 secretion on human epidermal keratinocytes.
The proinflammatory cytokine human interleukin-6 (hIL-6) plays an important role in the early and late courses of inflammation, trauma, and wound healing caused by sulfur mustard (HD). Previously, we demonstrated that hIL-6 might be involved in the early event of structural changes of the signal transducer glycoprotein, which indirectly initiates the cascade of events, such as skin irritation a...
متن کاملThe Role of Serum Level of Interleukin-6 in Severity of Pulmonary Complications of Sulfur Mustard Injuries
Diverse studies suggest that interleukin-6 (IL6), as a member of cytokines family, has a major role in inflammatory processes of airways and lungs. In this study, an attempt was made to determine the serum level of IL6 in sulfur mustard (SM) injured patients and its comparison with controls. The measured IL6 mean level in patients with chemical injuries (0.76±0.3 ng/ml) was significantly higher...
متن کاملRelationship of Interleukin-4 and Interleukin-6 with Pigmentation Disorders in Sardasht Sulfur Mustard-Exposed Veterans 20 Years after Exposure
Aims: Pigmentation disorders are one of the main skin problems due to mustard gas exposure in chemically-injured veterans. The aim of this study as part of the Sardasht cohort study was to investigate the association between IL-6 and IL-4 and pigment disorders in chemically-injured veterans exposed to mustard gas. Materials & Methods: In this study, 500 subjects including 372 people expose...
متن کاملthe role of serum level of interleukin-6 in severity of pulmonary complications of sulfur mustard injuries
diverse studies suggest that interleukin-6 (il6), as a member of cytokines family, has a major role in inflammatory processes of airways and lungs. in this study, an attempt was made to determine the serum level of il6 in sulfur mustard (sm) injured patients and its comparison with controls. the measured il6 mean level in patients with chemical injuries (0.76±0.3 ng/ml) was significantly higher...
متن کاملHuman marrow stromal cells: response to interleukin-6 (IL-6) and control of IL-6 expression.
Production of interleukin-6 (IL-6) by marrow stromal cells from human long-term marrow cultures and from stromal cells transformed with simian virus 40 was examined. As with other cultured mesenchymal cells, unstimulated stromal cells produced undetectable amounts of IL-6 mRNA when assayed by Northern blots. However, within 30 minutes after exposure of transformed marrow stromal cells to the in...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 2001
ISSN: 1091-5818,1092-874X
DOI: 10.1080/109158101753253027